Hypersensitivity to paracetamol: placebo effect or overdiagnosis?
نویسندگان
چکیده
منابع مشابه
Paracetamol hypersensitivity: a 5 year review
Methods A total of 245 patients with suspected NSAIDs HS were referred to our Drug Allergy Clinic from 2009 to 2013 and those with suspected PHS were evaluated. Demographic data, atopy, comorbidities, HS to other NSAIDs, timing of reaction, clinical manifestations and diagnostic procedures were assessed. PHS was confirmed by a positive DPT (drug provocation test) and considered probable based o...
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In 1955, Henry K. Beecher published the classic work entitled "The Powerful Placebo." Since that time, 40 years ago, the placebo effect has been considered a scientific fact. Beecher was the first scientist to quantify the placebo effect. He claimed that in 15 trials with different diseases, 35% of 1082 patients were satisfactorily relieved by a placebo alone. This publication is still the most...
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STUDY OBJECTIVE This randomized, placebo-controlled trial evaluates the analgesic efficacy and safety of intravenous single-dose paracetamol and morphine for the treatment of renal colic. METHODS We conducted a randomized, double-blind, placebo-controlled clinical trial comparing single intravenous doses of paracetamol (1 g), morphine (0.1 mg/kg), and placebo (normal saline solution) for pati...
متن کاملHypersensitivity pneumonitis associated with co-proxamol (paracetamol + dextropropoxyphene) therapy.
A 61-year-old man developed hypersensitivity pneumonitis and skin rash in close association with taking co-proxamol. These problems occurred in spite of being treated with prednisolone 40 mg daily (20 mg daily at the time of presentation) for assumed cranial arteritis. A therapeutic challenge with paracetamol was negative and the patient continues to take this drug. It seems likely that this pa...
متن کاملParacetamol-induced hypersensitivity vasculitis in a 10-year-old child.
We report a 10 year-old child who came to our observation for an itching erythematous-purpuric rash arranged in a reticular form over the entire skin surface, which persisted since two months (Figure 1). Four days before its onset, the child experienced a flu-like episode with high fever, treated with paracetamol (usually administered for fevers in this child, without any adverse effects). The ...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2018
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2017.12.140